Korean J Anesthesiol.  1998 Jul;35(1):7-15. 10.4097/kjae.1998.35.1.7.

The Effects of Amrinone and Milrinone on Myocardium in the Isolated Isoflurane-Exposed Rat Heart

• Kim SW
• Lee MK
• Yoon SM

• KMID: 2298902
• DOI: http://doi.org/10.4097/kjae.1998.35.1.7

Abstract

BACKGROUND
The aims of this study were to test if amrinone or milrinone reverses cardiac depression induced by the exposure to isoflurane in the isolated heart and to determine whether amrinone or milrinone dilates the coronary artery directly.
METHODS
Using the isolated Sprague-Dawley rat hearts, heart rate, left ventricular pressure, dp/dt (differentiated rate of pressure development), O2 delivery(DO2), myocardial oxygen consumption(MVO2), and percent O2 extraction were measured. After the isolated hearts were exposed to isoflurane at 1.2 vol% during 10 min, amrinone(10, 50, 100 M) or milrinone(1, 5, 10 M) was separately given to six groups.
RESULTS
Amrinone and milrinone reversed, not statistically significant, the depression of cardiac contractility induced by isoflurane, while the isoflurane-induced bradycardia substantially returned to normal by amrinone 100 M. And amrinone and milrinone elevated coronary flow, DO2, MVO2, while isoflurane increased in coronary flow and DO2, except MVO2.
CONCLUSIONS
These results suggest that amrinone and milrinone did not counteract the isoflurane-induced cardiac depression and indirectly increased in coronary blood flow through the elevation of cardiac work.

Keyword

Anesthetics, volatile: isoflurane; Pharmacology: amrinone; milrinone

MeSH Terms

Amrinone*
Animals
Bradycardia
Coronary Vessels
Depression
Heart Rate
Heart*
Isoflurane
Milrinone*
Myocardium*
Oxygen
Rats*
Rats, Sprague-Dawley
Ventricular Pressure
Amrinone
Isoflurane
Milrinone
Oxygen