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The Effect and Mechanism of the Specific Phosphodiesterase (PDE) III-Inhibitor Milrinone on Human and Rabbit Corpus Cavernosum

Jeon SS, Paick JS, Kim SW

  • KMID: 1914081
  • Korean J Urol.
  • 1996 Oct;37(10):1067-1074.
Milrinone is a positive inotropic/vasodilator agent in both preclinical and clinical studies. Milrinone has been shown previously to inhibit specific type III PDE isolated from different sources. To investigate the...
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The Effects of Amrinone and Milrinone on Myocardium in the Isolated Isoflurane-Exposed Rat Heart

Kim SW, Lee MK, Yoon SM

BACKGROUND: The aims of this study were to test if amrinone or milrinone reverses cardiac depression induced by the exposure to isoflurane in the isolated heart and to determine whether...
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Successful Opening of Ductus Arteriosus with Milrinone in a Newborn with Tetralogy of Fallot and Pulmonary Atresia

Won CB, Kim MY, Choi DY, Cho HJ, Shim SY, Son DW

Tetralogy of Fallot (TOF) assumes its' most severe form when accompanied by pulmonary atresia (PA). Preserving the patent ductus arteriosus to maintain pulmonary blood flow is life-saving for patients with...
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Hemodynamics of Milrinone and Low-Dose Vasopressin Infusion during OPCAB

Jeon Y, Kim D, Yoon T, We S, Yoon S, Park J, Ham B

BACKGROUND: AVP (arginine vasopressin) shows unique hemodynamic characteristics, as a vasopressor. AVP has been tried in many cathecholamine refractory vasodilatory situations, and sometimes resulted in effective hemodynamic improvement. In this...
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The Effect of Isoproterenol, Dobutamine, and Milrinone on Pulmonary Vasoconstriction in Isolated Rat Lungs

Oh AY, Park HY, Kim KO, Kim SD

BACKGROUND: Dobutamine, isoproterenol, and milrinone are inotropic agents with vasodilatory properties, and are frequently used perioperatively. We undertook to examine the effects of these three drugs on the pulmonary vasculature,...
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Safety and Efficacy of the Off-Label Use of Milrinone in Pediatric Patients with Heart Diseases

Lee J, Kim GB, Kwon HW, Kwon BS, Bae EJ, Noh CI, Lim HG, Kim WH, Lee JR, Kim YJ

BACKGROUND AND OBJECTIVES: Milrinone is often used in children to treat acute heart failure and prevent low cardiac output syndrome after cardiac surgery. Due to the lack of studies on...
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Does Milrinone Improve Hemodynamic Variables in Patients with Pulmonary Hypertension Due to Valvular Heart Disease?

Shim YH, Oh YJ, Nam SB, Kim E, Hong YW, Kwak YL

BACKGROUND: Milrinone is a bipyridine phosphodiesterase III inhibitor that exerts both positive inotropic and direct vasodilatory effects. The efficacy and safety of intravenous milrinone in heart failure has been evaluated...
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The Effect of Milrinone on the Right Ventriclular Function in Patients with Reduced Right Ventricular Function Undergoing Off-pump Coronary Artery Bypass Graft Surgery

Lee JH, Oh YJ, Shim YH, Hong YW, Yi G, Kwak YL

This investigation evaluated the effect of continuous milrinone infusion on right ventriclular (RV) function during off-pump coronary artery bypass graft (OPCAB) surgery in patients with reduced RV function. Fifty patients...
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Experience of Milrinone Treatment for Persistent Pulmonary Hypertension of the Newborn

In DK, Yang SW, Hong HJ, Choi DY, Sun YH, Ryoo E, Cho KH, Jung MJ, Jeon IS, Tchah H, Son DW, Shim SY

  • KMID: 2099105
  • J Korean Soc Neonatol.
  • 2006 Nov;13(2):201-208.
PURPOSE:Persistent pulmonary hypertension of the newborn (PPHN) is life threatening neonatal disease. Nitric oxide (NO) has been proven to improve oxygenation, however its usage is limited and 30% of patients...
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The effect of milrinone infusion on right ventricular function during coronary anastomosis and early outcomes in patients undergoing off-pump coronary artery bypass surgery

Jo HR, Lee WK, Kim YH, Min JH, Chae YK, Choi IG, Kim YS, Lee YK

BACKGROUND: During coronary anastomosis in off-pump coronary artery bypass surgery (OPCAB), hemodynamic alternations can be induced by impaired diastolic function of the right ventricle. This study was designed to examine...
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Effectiveness of milrinone for cardiogenic shock due to massive pulmonary aspiration: a case report

Park JH, Kwon MA, Kim DH, Kim SK, Jeon DG, Song J, Ji SH, Lee GW, Kang BJ

Pulmonary aspiration of gastric contents is one of the most frightening complications during anesthesia. Although pulmonary aspiration of gastric contents in general surgical patients is not common and resulting long-term...
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The effect of milrinone on the intraoperative hemodynamics during off-pump coronary bypass surgery in patients with an elevated echocardiographic index of the ventricular filling pressure

Song JW, Jo YY, Jun NH, Kim HK, Kwak YL

BACKGROUND: Hemodynamic derangement during off-pump coronary artery bypass surgery (OPCAB) is mainly attributed to impaired filling and diastolic dysfunction. An elevated ratio of the mitral velocity to the early-diastolic velocity...
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The vasorelaxatory effect of the milrinone on the preconstricted rat aorta

Kwon HU, Park JT, Ryoo S, Park IH, Lee SH, Kim SY, Yoon SH, Lim HK

BACKGROUND: Milrinone, phosphodiesterase III inhibitor, has been used effectively in patients with right heart failure, especially resulted from pulmonary hypertension. However, milrinone is often used with alpha- and beta-adrenergic receptor...
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The Combined Effect of Desflurane and Milrinone on the Function of the Isolated Rat Heart

Yoon JR, Kong MH, Kim KN, Lee IO, Lee MK, Lim SH, Choi YS, Kim NS

BACKGROUND: Desflurane depresses the contractile function of the myocardium. It also causes direct coronary vasodilation. Milrinone, a phosphodiesterase III inhibitor, usually increases myocardial contractility and also has vasodilatory activity. Some...
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Effect of milrinone on the inflammatory response and NF-kB activation in renal ischemia-reperfusion injury in mice

Jung HS, Joo JD, Kim DW, In JH, Roh M, Jeong JT, Noh SJ, Choi JW

BACKGROUND: Milrinone increases intracellular adenosine 3',5'-cyclic monophosphate concentration and enhances vascular relaxation. Nuclear factor-kappa B (NF-kB) plays a key role in inflammatory responses during ischemia-reperfusion (I/R) injury. We aimed to...
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Comparision of the Hemodynamic Effects of Dopamine and Milrinone in Patients Undergoing Off-Pump Coronary Artery Bypass Grafting

Yang DS, Cho IH, Lee SK, Kim YM, Song HJ, Moon HS

BACKGROUND: Off-pump coronary artery bypass grafting (OPCAB) on the beating heart causes hemodynamic compromise during displacement of the heart for graft anastomosis. To overcome hemodynamic unstability, volume loading, Trendelenburg position,...
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Atrial Fibrillation during Ethanol Sclerotherapy in a Patient with Lower Limb Arteriovenous Malformation: A case report

Chung IS, Choi SJ, Lee SM, Gwak MS, Yoon JS

Alcohol embolization or sclerotherapy has been commonly used for a treatment of arteriovenous malformation (AVM). Alcohol sclerotherapy frequently produces minor local complications but may rarely produce catastrophic cardiopulmonary complications. In...
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What do we take consideration in the patient who has an unpredicted severe portopulmonary hypertension in liver transplantation?: a case report

Koh H, Ahn S, Lee J

Severe portopulmonary hypertension (PPHT) is considered a contraindication for liver transplantation (LT) because of the associated high mortality and poor prognosis. We report the case of a 57-year-old cirrhotic woman...
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Left Ventricular Noncompaction Complicated with Myocardial Infarction with Barth Syndrome in a Newborn

Yoo GH

Left ventricular noncompaction (LVNC) is a rare cardiomyopathy characterized by a hypertrabeculation of the left ventricle. Patients may present with heart failure, arrhythmia, and thromboembolism. LVNC may be isolated or...
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Anesthetic management for emergent craniotomy in a patient with Eisenmenger's syndrome: A case report

Chung KH, Kim SH, Chun DH, Lee JY, Park SC, Park CH, Kim MG

Eisenmenger's syndrome describes the elevation of pulmonary arterial (PA) pressure to the systemic level caused by an increased pulmonary vascular resistance with reversed or bi-directional shunt through an intracardiac or...
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