Korean J Androl.  2009 Apr;27(1):31-35.

The Effect of Cardiovascular Risk Factors on the Patient with Erectile Dysfunction and Diabetes and the Response to Phosphodiesterase Type 5 Inhibitors

• Sohn DW
• Kim SI
• Kim SD
• Kim DB
• Kim JS
• Song KH
• Kim SW

Abstract

PURPOSE
Erectile dysfunction (ED) is a common comorbidity with diabetes mellitus (DM). The goal of this study was to evaluate the effect of cardiovascular risk factors (CVRF) on ED patients with DM and the response to phosphodiesterase type-5 (PDE5) inhibitors.
MATERIALS AND METHODS
We performed a retrospective study on 32 patients with ED and type II DM. The CVRFs were defined as hypertension, coronary artery disease, hyperlipidemia, smoking and obesity. All the patients were checked for CVRFs and the erectile function was assessed with the International Index of Erectile Function (IIEF) score. Tadalafil (20mg) was taken for 3 months, and then the IIEF score was checked again. The scores of the IIEF-EF, Q3 and Q4 and the number of risk factors were analyzed.
RESULTS
The scores of the IIEF-EF, Q3 and Q4 were higher in the non-risk factor group than that in the risk factor group. After Tadalafil treatment, the score of the group that had less than 1 risk factor was significantly improved, but the score of the group that had more than 2 risk factors showed little change.
CONCLUSIONS
To treat ED patients with DM, their cardiovascular risk factors must be assessed.

Keyword

Diabetes Mellitus; Erectile dysfunction; Cardiovascular risk factor

MeSH Terms

Carbolines
Comorbidity
Coronary Artery Disease
Diabetes Mellitus
Erectile Dysfunction
Humans
Hyperlipidemias
Hypertension
Male
Obesity
Phosphodiesterase 5 Inhibitors
Retrospective Studies
Risk Factors
Smoke
Smoking
Tadalafil
Carbolines
Phosphodiesterase 5 Inhibitors
Smoke