Korean J Androl.  2009 Dec;27(3):153-169.

New Approach and Treatment of Premature Ejaculation

• Kam SC
• Lee SW

Abstract

Premature ejaculation (PE) is the most common form of male sexual dysfunction. Until very recently, scientific investigation of PE has been hampered by a lack of standardized definitions and objective, validated questionnaires. In recent years both the definition and the management of PE have changed from the traditional authority-based to a more evidence-based approach. In 2007, the International Society for Sexual Medicine (ISSM) established an ad hoc committee consisting of 21 internationally recognized experts, to establish a new definition of PE including intravaginal ejaculation latency time (IELT). As diagnostic tools, a brief self-administered questionnaire, the premature ejaculation diagnostic tool (PEDT), was developed and validated. Current accepted treatment options of PE include behavior therapy, topical desensitizing agents, selective serotonin reuptake inhibitors (SSRIs), clomipramine, tramadol, PDE-5 inhibitors. However, it should be noted that all of the medications currently used for treatment of PE were originally developed to treat other medical disorders such as depression or erectile dysfunction. Dapoxetine, a new SSRI, has a unique pharmacokinetic profile, with a short time to maximum serum concentration, and rapid elimination. By 24 hours, plasma concentrations are less than 5% of peak values. These attributes make Dapoxetine suitable for on-demand therapy of PE. This paper reviewed new diagnostic tools and treatment options for PE.

Keyword

Premature ejaculation; Intravaginal ejaculation latency time; Selective serotonin reuptake inhibitors; Dapoxetine

MeSH Terms

Behavior Therapy
Benzylamines
Clomipramine
Depression
Ejaculation
Erectile Dysfunction
Humans
Male
Naphthalenes
Phosphodiesterase 5 Inhibitors
Plasma
Premature Ejaculation
Surveys and Questionnaires
Serotonin Uptake Inhibitors
Tramadol
Benzylamines
Clomipramine
Naphthalenes
Phosphodiesterase 5 Inhibitors
Serotonin Uptake Inhibitors
Tramadol