J Rhinol.  2015 May;22(1):1-5. 10.18787/jr.2015.22.1.1.

Development and Utilization of a Mouse Model of Nasal Polyps

• Kim SW
• Jeon SY
• Kim DW

• KMID: 2297547
• DOI: http://doi.org/10.18787/jr.2015.22.1.1

Abstract

Systemic corticosteroids currently represent the most effective treatment for chronic rhinosinusitis with nasal polyps (CRSwNP), but their long-term use is constrained due to their detrimental side effects. Until recently, development of novel drugs for CRSwNP has been difficult partly due to the absence of a standard animal model of CRSwNP. Exotoxins of Staphylococcus aureus such as staphylococcal enterotoxin B (SEB), are well-known superantigens which can induce a strong immune response; there have been many studies on the association of staphylococcal enterotoxins and development of CRSwNP over the past two decades. Based on previous studies, we invented a mouse model of CRSwNP using SEB. Herein, we explain the protocol development for the mouse model, as well as identify histological and immunological similarities between this mouse model and humans. Furthermore, we describe a study that analyzed the risk factors for CRSwNP such as smoking, and also elaborate on a series of studies that searched for new potential drugs for CRSwNP, including resveratrol, anti-periostin antibody, topical hypoxia-inducible factors, and topical cyclosporine. Based on preceding studies, we have concluded that this mouse model might be a useful tool to investigate the pathophysiology and development of novel drugs for CRSwNP.

Keyword

Models, animal; Mouse; Nasal polyps; Sinusitis therapeutics

MeSH Terms

Adrenal Cortex Hormones
Animals
Cyclosporine
Enterotoxins
Exotoxins
Humans
Mice*
Models, Animal
Nasal Polyps*
Risk Factors
Smoke
Smoking
Staphylococcus aureus
Superantigens
Adrenal Cortex Hormones
Cyclosporine
Enterotoxins
Exotoxins
Smoke
Superantigens

Reference

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