J Korean Acad Fam Med.  1997 Jul;18(7):688-696.

Influence of food intake on the effect of intermediate action sulfonylurea

• Hwang IH
• Kim SY

Abstract

BACKGROUND: Sulfonylurea is recommended to be taken before meal. But since premeal administration is against Koreans usual medication habit, it can be the cause of poor compliance. Such recommendation is based on the results of a few clinical trials about appropriate medication time. But most of the clinical studies had a limitation : observe only acute effects of medication, subjects were only healthy volunteer. So the chronic effect of sulfonylurea of each kind must be validated.
METHODS
From 1996 May to 1996 July, data were collected from diabetic patients who visited an university hospitals for managing diabetes and used a intermediate-acting sulfonylurea. The subjects were randomized to two groups of premeal group and postmeal group, by chart number and were asked to take the previous medicine according to assignment. After 1 month medication, mixed meal tolerance test was done with 300Kcal carbohydrate, 400+/-50Kcal diet. The subjects were switched to the other group and 2nd mixed meal tolerance test was done 1 month later. The Area under curves was calculated in preand post-prandial glucose curve and was compared by paired t-test.
RESULTS
During the study period, total 16 diabetic patients were enrolled. There was no significant statistical difference between pre-prandial group and post prandial group in AUC.
CONCLUSIONS
Intermediate-acting sulfonylurea can be administered at any time in relation to meaL.

MeSH Terms

Area Under Curve
Compliance
Diet
Eating*
Glucose
Healthy Volunteers
Hospitals, University
Humans
Meals
Glucose