J Korean Acad Fam Med.  2007 Aug;28(8):610-615.

The Validity of Michigan Neuropathy Screening Instrument as a Screening Test and Risk Factors for Diabetic Peripheral Neuropathy

• Choi HY
• Do HJ
• Oh SW
• Lym YL
• Choi JK
• Joe HG
• Kweon HJ
• Cho DY

Abstract

BACKGROUND: Diabetic neuropathy is a common complication of diabetes. Since neuropathy leads to ulceration and amputation, efforts to detect early and to elucidate its risk factors are ongoing. The goal of this study was to check the validity of Michigan neuropathy screening instrument (MNSI) as a screening test and its risk factors for diabetic neuropathy.
METHODS
A total of 75 subjects with type II diabetes mellitus, who visited a university hospital, were investigated. We measured their duration of diabetes, height, weight, systolic blood pressure, diastolic blood pressure, fasting glucose, glycosylated hemoglobin, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, total cholesterol, serum creatinine, and 24-h urine albumin. MNSI tested and electrophysiological test were performed.
RESULTS
The sensitivity, specificity, positive predictive value, and negative predictive value of MNSI was 63.5%, 78.3%, 86.8%, and 48.6%, respectively. Statistically significant relationships were found between neuropathy and the duration of diabetes and total cholesterol.
CONCLUSION
MNSI seemed to be an appropriate screening test for diabetic neuropathy. More attention must be paid to the duration of diabetes and the total cholesterol of type 2 diabetic patients with peripheral neuropathy.

Keyword

michigan neuropathy screening instrument; diabetic neuropathy; risk factor

MeSH Terms

Amputation
Blood Pressure
Cholesterol
Creatinine
Diabetes Mellitus
Diabetic Neuropathies
Fasting
Glucose
Hemoglobin A, Glycosylated
Humans
Lipoproteins
Mass Screening*
Michigan*
Peripheral Nervous System Diseases*
Risk Factors*
Sensitivity and Specificity
Triglycerides
Ulcer
Cholesterol
Creatinine
Glucose
Lipoproteins