Korean J Urol.  2005 Mar;46(3):229-233.

Risk Factors for the Development of Bladder Transitional Cell Carcinoma Following Surgery for Transitional Cell Carcinoma of the Upper Urinary Tract

• Kim KH
• Park JS
• Kim CI
• Lee KS

Abstract

PURPOSE: The purpose of this study was to determine the clinical and pathological risk factors for initial intravesical recurrence in patients following surgery for a transitional cell carcinoma of the upper urinary tract.
MATERIALS AND METHODS
67 patients surgically treated for a transitional cell carcinoma of the upper urinary tract, between 1994 and 2003, were reviewed. We excluded the patients with a concomitant bladder tumor or previous bladder tumor. Traditional prognostic factors, including age, gender, tumor stage, grade, location, multiplicity, structure, size, urine cytology, operation method and adjuvant chemotherapy, were analyzed with respect to disease recurrence to the bladder.
RESULTS
The initial intravesical recurrence in patients following surgery for a transitional cell carcinoma of the upper urinary tract was found in 18 patients (26.9%) during a average follow-up period of 23 months (range 6 to 118). A univariate analysis of the 67 patients showed that the tumor stage and grade were significantly correlated with the incidence of a subsequent bladder tumor. On multivariate analysis, the tumor stage had a significant impact on a subsequent bladder tumor.
CONCLUSIONS
The tumor stage was an important predictor of recurrence to the bladder in patients treated surgically for a transitional cell carcinoma of the upper urinary tract. For patients with a transitional cell carcinoma of the primary upper urinary tract, regular follow-up by cystoscopy and urine cytology are necessary for the detection of recurrent bladder tumors.

Keyword

Transitional cell carcinoma; Urinary tract; Bladder neoplasm; Recurrence

MeSH Terms

Carcinoma, Transitional Cell*
Chemotherapy, Adjuvant
Cystoscopy
Follow-Up Studies
Humans
Incidence
Multivariate Analysis
Recurrence
Risk Factors*
Urinary Bladder Neoplasms
Urinary Bladder*
Urinary Tract*