Risk Factors for Subsequent Bladder Tumor in Upper Tract Urothelial Tumor

Kim, Gun Pyung; Kim, Hyun Hag; Oh, Bong Ryoul; Kim, Hyung Jin; Ryu, Soo Bang; Park, Young Kyung; Park, Yang Il

Abstract

PURPOSE: To determine the clinical and pathological risk factors for subsequent bladder tumor in patients with primary upper tract urothelial tumor, we retrospectively analyzed patients with upper tract urothelial tumor, focusing on the clinicopathological features of subsequent bladder tumor.
MATERIALS AND METHODS
Risk factors, disease free rate and survival were assessed with clinicopathological features in 56 patients with upper tract urothelial tumor operated between 1989 and 1998. We excluded the patients with lymph node metastasis or distant metastasis, those with a short period of follow-up, and those having a previous history of bladder tumor. Risk factors such as sex, age, location of tumor, size of tumor, number of tumor, synchronous bladder tumor, preoperative urine cytology, stage, grade, operation method, and adjuvant chemotherapy were investigated.
RESULTS
Initial subsequent bladder tumor was found in 36 patients (53.6%) during follow-up period of 44 months (range 13 to 111). Among several clinicopathological factors examined, only urine cytology was significantly correlated with the incidence of subsequent bladder tumor (p<0.05). Sex, age, location of tumor, size of tumor, number of tumor, synchronous bladder tumor, stage, grade, operation method, or adjuvant chemotherapy did not affect subsequent bladder tumor recurrence. There was no significant difference in survival rates between the patients with and without subsequent bladder tumor.
CONCLUSIONS
Of the clinical and pathological risk factors for subsequent bladder tumor in patients with primary upper tract urothelial tumor, only preoperative urine cytology was significantly correlated with subsequent bladder tumor.