J Korean Acad Child Adolesc Psychiatry.
2011 Sep;22(3):141-148.
Clinical Characteristics of Developmental Regression in Autism Spectrum Disorders
- Affiliations
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- 1Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea. soochurl@snu.ac.kr
- 2Department of Neuropsychiatry, Seoul National University Bungdang Hospital, Seongnam, Korea.
- 3Department of Psychiatry, Gachon University Gill Hospital, Gachon University of Medicine and Science, Incheon, Korea.
- 4Department of Psychiatry, Chungbuk National University Hospital, Cheongju, Korea.
- 5Department of Psychiatry, Chonbuk National University Hospital, Jeonju, Korea.
- 6Department of Psychiatry, Kyungpook National University, Daegu, Korea.
- 7Department of Neuropsychiatry, Inje University Hospital, Busan, Korea.
Abstract
OBJECTIVE
A significant proportion of children with autism spectrum disorders (ASD) have regression characterized by loss of previously acquired skills. The purpose of this study was to compare demographic, clinical characteristics and autism-related symptomatology of the children who have regression with children who don't have regression.
METHODS
The subjects with ASD and their unaffected siblings (SIB) were recruited from the Korean Autism Genetic Study Consortium. Typically developing children (TC) were volunteered from community. The subjects were administered the Korean version of Autism Diagnostic Interview-Revised (K-ADI-R) and the Korean version of Autism Diagnostic Observation Schedule (K-ADOS) to diagnose or exclude ASD. Regression was defined on the basis of K-ADI-R data. The Korean version of Vineland Adaptive Behavior Scale (K-VABS), Aberrant Behavior Checklist (K-ABC) and Social Responsiveness Scale (K-SRS) were obtained from their parents.
RESULTS
Regression occurred in 8.33% (n=14) of children with ASD (n=168). Any SIB (n=166) and TC (n=53) did not experience regression. Regression was associated with lower IQ and lower score of K-VABS. There was no difference in autism symptom severity and K-ABC, K-SRS scores, between children with ASD who experienced regression and who did not.
CONCLUSION
Regression seems to be a distinctive feature of ASD. Regression is associated with cognitive and more general functions, rather than symptoms specific to autism.
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