Urodynamic Studies of the Voiding Disorders in Patients with Idiopathic Parkinson`s Disease and Multiple System Atrophy

Lee, Min Chong; Mah, Sang Yol

Abstract

PURPOSE: The onset and severity of voiding dysfunction in multiple system atrophy(MSA) is more early and severe than that of idiopathic Parkinson's disease(IPD). We compared the voiding symptoms and urodynamic findings in patients with MSA and IPD in order to elucidate the characteristics of their voiding dysfunction.
MATERIALS AND METHODS
We reviewed urodynamic data from 19 men and 10 women with parkisonism. Of the 29 patients(mean age 66.5 years), 19 patients (mean age 68.7 years) had IPD and 10 patients(mean age 62.4 years) had MSA. The mean duration of the disease in all patients was 4 years and 10 months, and there was no significant difference between IPD and MSA.
RESULTS
Detrusor hyperreflexia(DH) was seen in 8 patients, detrusor hypereflexia with impaired detrusor contractility(DHIC) in 3, detrusor hyperreflexia with bladder outlet obstruction(DHOB) in 4, impaired detrusor contractility(If) in 8, and normal findings in 6. In IPD, DH was noted in 5 patients, DHIC in 3, DHOB in 2, IC in 5 and normal in 4, and a similar distribution was seen in MSA. However, there was no significant difference in the prevalence of involuntary detrusor contraction between IPD and MSA. Irritative voiding symptoms were seen in 11 patients, obstructive symptoms in 10, and both in 8. Obstructive symptoms were dominate in IPD and irritative symptoms in MSA. Impaired relaxation of the voluntary sphincter was seen in 12(41%) patients with parkisonism,8 in IPD, and 4 in MSA. CONCLUSIONS: There was no difference between idiopathic Parkinson's disease and multiple system atrophy in mean age, sex, mean duration of disease, subjective voiding symptoms and urodynamic findings. Disease specific findings were not identified in patients with parkinsonism.