Studies on the Functions of the Graft Kidney Immediately After the Transplantation

Kwon, Sung Won

Abstract

As an attempt to elucidate the functional changes of the transplanted kidney with particular emphasis on the immediate postoperative periods, various renal functions of the graft kidney were compared with that of the remaining normal kidney after auto and homotransplantation in the dog. The results are summarized briefly as follows: 1. Glomerular filtration rate(GFR) and renal plasma flow (RPF) of the graft kidney was approximately 50 to 60 per cent of the normal kidney immediately following operation both in auto and homotransplantation. 2. Fraction of filtered water and electrolytes excreted was significantly greater in graft kidney and seemed to be caused by transient tubular damage. 3. The maximum concentration ability of urine in the graft kidney was significantly reduced. 4. Transfer maxima for PAH secretion of the graft kidney was reduced proportionately as the reduction of renal plasma flow, thus not affecting the tubular perfusion ratio. 5. The magnitude of splay in the PAH titration curve was identical between control and graft kidney. These findings suggest that intrarenal distribution of the blood flow is not altered in the graft kidney immediately following operation.