Studies on Seminal Fructose, plasma Testosterone, Follicle-Stimulating Hormone and Luteinizing Hormone

Park, Kyu Hong; Lee, Hee Yong

Abstract

Seminal fructose in conjunction with plasma testosterone, follicle-stimulating hormone FSH),and luteinizing hormone (LH) was measured on the forty Korean adult males. These subjects were divided into four study groups, such as : Group I: Twenty cases of normospermic males. Group II: Ten cases of obstructive azoospermic males with normal or obstructive change in testis, Group III case at non-obstructive azoospermic males with hypospermatogenesis or spermatogenic arrest at various levels in testis. Group IV: Four cases of non-obstructive azoospermic males with severe seminiferous tubular atrophy and/or hyalinization, or germ cell aplasia with Sertoli cell only in testis. The results are analysed based on the following factors. 1. The average values are: seminal fructose is 301.5 mg/dl(range,131-485): plasma testosterone, 730.4mg/dl(range,420-1160): FSH, 121 mIU/ml(range,6.5-20.0) and LH,9.2 mIU/ml(range,5.3-15.9) in group I. Seminal fructose is 315.2 mg/dl(range,160-386 ); plasma testosterone, 640.0 ng/dl (range,392-840); FSH,3.2 mIU/ml(range,1.0-7.6); LH,4.2 mIU/ml(range 0.5-3.8) in group II. Seminal fructose is 257.2mg/dl(range,120-400): Plasma testosterone, 618.8 ng/dl(range,416-824): FSH,6.6 mIU/ml (range,1.0-13.0); LH,7.3 mIU/ml (range,408-664); FSH,29.9 mIU/ml(range,19.0-50.0); LH,12.1 mIU/ml(range,7.6-16.0) in group IV. 2. Seminal fructose, Plasma testosterone, FSH and LH values are remained in physiologic ranges in all subjects of group II, even Leydig cell hyperplasia is moderate in 4 cases. 3. Seminal fructose, Plasma testosterone, FSH and LH values are also remained in physiologic ranges in all subjects of group III, even moderate Leydig cell hyperplasia is found in 1 case. 4. Low Plasma testosterone(p<0.01), high FSH(p<0.05), and LH(p>0.1) values are consistent in group IV, even though severe Leydig cell hyperplasia exists in all cases except one. 5. No statistical correlations are noted between plasma testosterone in the range of 392-1160 mg/dl and seminal fructose in the range of 120-485mg/dl.(r=0.190,p>0.1) But seminal fructose is not significantly low when plasma testosterone is not remarkably decreased. 6. The seminal fructose in the range of 120-485 mg/dl is not under the influence of plasma FSH(range,1.0-20.0mIU/ml). 7. Low plasma testosterone in spite of severe Leydig cell hyperplasia in group IV suggests complexity of Leydig cell responsiveness to LH.