Korean J Thorac Cardiovasc Surg.
2002 May;35(5):336-342.
The Effects of Muscle Cell Transplantation into the Hearts of the Hamsters with a Dilated Cardiomyopathy
- Affiliations
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- 1Division of Cardiovascular surgery, Yonsei Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea. kjy@yumc.yonsei.ac.kr
- 2Yonsei Cardiovascular Research Institute, Yonsei Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.
Abstract
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BACKGROUND: Recently, cell transplantation has been extensively investigated to improve heart function in dysfunctional heart. This study was designed to compare the effects of smooth muscle cells (SMC) and heart cells (HC) transplantation in dilated cardiomyopathic hamsters.
MATERIAL AND METHOD: HC and SMC were isolated from heart and ductus deferens of BIO 53.58 hamsters, and cultured for transplantation. HC and SMC or culture medium were transplanted into the left ventricle of 17 weeks old adult hamsters in HC transplantation (HCTx), SMC transplantation (SMCTx), and control groups (Con) (N=10 each). Cyclosporine (5 mg/Kg) was administered subcutaneously for HCTx. Sham operated hamsters (N=10) underwent the surgery but did not receive an injection. At 4 weeks after transplantation, heart function was evaluated in all groups using a Langendorff perfusion apparatus.
RESULT: Histology showed severe focal myocardial necrosis in all groups. HCTx and SMCTx formed huge muscle tissue in dilated myocardium. SMCTx and HCTx had better heart function than Con and sham (p < 0.01). And SMCTx had better peak systolic pressure (p < 0.05) and developed pressure (p < 0.05) than HCTx. But sham and Con did not any statistical make difference.
CONCLUSION
SMCTx and HCTx formed muscle tissue and improved ventricular function in hamsters with dilated cardiomyopathy. And SMCTx showed better heart function in peak systolic pressure and developed pressure than HCTx.
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