J Genet Med.  2007 Dec;4(2):128-132.

A study on association of progesterone receptor gene polymorphism (PROGINS) with Endometriosis

• Kim YJ
• Noh JH
• Koh JW
• Kim YB

Abstract

PURPOSE: Endometriosis is a steroid dependent disease with a particular genetic background but the location of possible genomic aberrations are still poorly clarified. This study was designed to investigate the associations between the polymorphism of the progesterone receptor gene (PROGINS) and endometriosis.
METHODS
100 women with surgically diagnosed and histologically confirmed endometriosis were enrolled as a patient population and a total of 110 female control subjects undergoing health examination were enrolled as control population. DNA extraction and polymerase chain reaction (PCR) were used to genotype women for the presence of the PROGINS polymorphism in peripheral blood samples. The x2-test was used to compare genotype distributions between endometriosis and controls.
RESULTS
T1/T2 heterozygote was found to be one patient in each group, and the rest of the subjects were all T1/T1 homozygotes. There was no difference in the genotype distribution between the endometriosis group and the control group.
CONCLUSION
These results suggest that the progesterone receptor gene PROGINS is not associated with the risk for endometriosis.

Keyword

PROGINS; Progesterone receptor; Polymorphism

MeSH Terms

DNA
Endometriosis*
Female
Genotype
Heterozygote
Homozygote
Humans
Polymerase Chain Reaction
Progesterone*
Receptors, Progesterone*
DNA
Progesterone
Receptors, Progesterone