Korean J Psychopharmacol.
1997 Apr;8(1):69-78.
The Therapeutic Effect of Sertraline in Treatment-resistant Schizophrenics
- Affiliations
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- 1Seoul National Mental Hospital, Seoul, Korea.
- 2Department of Psychiatry, College of Medicine, Ewha Woman's University, Seoul, Korea.
Abstract
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OBJECT: This study was undertaken to know whether there is any therapeutic effecets of sertraline in treatment-resistant schizophrenics.
METHOD: Seventy seven treatment-resistant schizophrenic patients, to whom the same antipsychotics as usual were administered, were randomly assigned to two groups; to the experimental group, sertraline was and to the controlled group, placebo was administered adjuntively for 6weeks in single blind design. We assessed psychopathology by BPRS, PANSS, YBOCS, HRSD, and SCL-90-R.
RESULTS
BPRS, positive scale of PANSS, and HRSD were significantly decreased in experimental group and statistically siginificant differences between the experimental group and placebo group. Negative scale of PANSS and YBOCS were significantly decresed in experimental group but no statistically significant differences between the experimental group and placebo group. The therapeutic effect of sertraline was occurred within 3rd weeks.
CONCLUSION
We suggested that sertraline may be useful in the treatment of schizophrenic symtom in treatment-resistent schizophrenia, especially in positive and depressive symptoms.
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