J Bone Metab.  2014 Aug;21(3):223-226. 10.11005/jbm.2014.21.3.223.

Intravenous Zoledronate for a Patient with Paget's Disease

• Kim KC

• KMID: 2286293
• DOI: http://doi.org/10.11005/jbm.2014.21.3.223

Abstract

Paget's disease (PD) of bone is characterized by increase of bone resorption by atypical osteoclasts, followed by rapid new bone formation resulting in a disorganized mosaic bone. Although the pathophysiology is not fully understood, bisphosphonate, which is a potent anti-resorptive agent for treatment of osteoporosis, have been the most effective agents available for the treatment of PD. We report a case of PD of bone in a 49-year-old woman patient, who was treated with intravenous zoledronate.

Keyword

Bone density conservation agents; Diphosphonates; Osteitis deformans

MeSH Terms

Bone Density Conservation Agents
Bone Resorption
Diphosphonates
Female
Humans
Middle Aged
Osteitis Deformans
Osteoclasts
Osteogenesis
Osteoporosis
Bone Density Conservation Agents
Diphosphonates

Figure

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  Fig. 1 Bone scan showed hot uptake in left ilium and acetabulum.

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  Fig. 2 Pelvis anterior-posterior radiograph revealed a mosaic pattern in left pubis and ilium around sacroiliac joint.

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  Fig. 3 The bone scan, which was obtained 3 months after administration of oral pamidronate, showed increased uptake in left ilium and acetabulum.

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  Fig. 4 The bone scan, which was obtained 6 months after administration of intravenous zoledronate, had no increased uptake in pelvis.

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  Fig. 5 Bone scan showed hot uptake in both ilium and lumbar vertebrae, when she visited again our hospital 19 months after administration of intravenous zoledronate.

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  Fig. 6 The bone scan, which was obtained 12 months after second administration of zoledronate, revealed no increased uptake in pelvis and lumbar vertebrae.

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