J Asthma Allergy Clin Immunol.
2001 Jun;21(3):500-507.
Localization of transforming growth factor beta1 in airway mucosa of toluene diisocyanate-induced asthma
- Affiliations
-
- 1Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon. hspark@madang.ajou.ac.kr
- 2Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine, Suwon.
- 3Department of Gastroenterology, Ajou University School of Medicine, Suwon.
- 4Department of Anatomical Pathology, Ajou University School of Medicine, Suwon
- 5SoonChunHyang University, Seoul, Korea.
Abstract
-
BACKGROUND AND OBJECTIVE: There have been some reports on the expression of TGF beta-an anti-inflammatory and fibrosing cytokine in airway mucosa of asthmatics. However, the ex- pression of TGF beta1 in bronchial mucosa of TDI-induced asthma is not known. The aim of this study was to observe immunolocalization of TGF beta1 in airway mucosa of TDI-induced asthma.
METHODS
TGF beta1 expressions were compared using immunohistochemistry in bronchial muco- sa from 22 subjects with TDI-induced asthma (group I: 10 newly diagnosed, group II: 12 subjects with persistent asthma symptoms for more than 4 years after diagnosis), and 8 non- asthmatics undergoing pneumonectomy from lung tumor. The distribution and intensity of expression were analyzed by two observers in four areas of bronchial tissue-epithelium(EP), vascular endothelium(VE), smooth muscle(SM), and mucous glands(MG).
RESULTS
Positive rates of TGF beta1 expression for groups I and II in the four areas were as follows; EP (50% vs 100%, p<0.05), VE(40% vs 100%, p<0.05), SM(33.3% vs 100%, p<0.05), and MG(66.7% vs 80%, p>0.05). Grades of TGF beta1 expression of EP, VE, and SM were significantly higher in group II than in group I(p<0.05, respectively). There was no significant difference in distribution and intensity of TGF beta1 expression between TDI-induced asthma and controls(p>0.05, respectively).
CONCLUSION
TGF beta1 expressions of EP, VE, SM and MG were noted in airway mucosa of TDI-induced asthma and expressions of EP, VE, and SM were more intense and frequent in patients with persistent asthma symptoms.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Expression of epidermal growth factor receptor (EGFR) and transforming growth factor beta1 (TGF beta1) in airway mucosa of toluene diisocyanate (TDI)-induced asthma patients
- A case of occupational asthma with systemic illness due to toluene diisocyanate and diphenylmethane diisocyanate
- Expression of transforming growth factorbeta1 (TGFbeta1) and TGFbeta receptor II (R II) in airway mucosa of toluene diisocyanate (TDI)-induced asthma: relationships with persistent asthmatic symptoms
- The Transforming Growth Factor-beta1 Expression in Normal Laryngeal Mucosa, Laryngeal Dysplasia and Laryngeal Carcinoma
- A case of bronchial asthma induced by toluene diisocyanate(TDI) in the external environment
