J Agric Med Community Health.  2012 Mar;37(1):23-35.

Relationship of Average Volume of Alcohol Consumption and Binge Drinking to Arterial Stiffness in Community-Dwelling Healthy Adults

• Kweon SS
• Lee YH

Abstract

OBJECTIVES
The purpose of this study was to investigate the association of the average volume of alcohol consumption and binge drinking with arterial stiffness.
METHODS
The study population consisted of 5944 community-dwelling healthy adults aged 50 years and older. Average volume of alcohol consumption was calculated and frequency of binge drinking defined as the consumption of 7 or more drinks for men and 5 or more for women on a single occasion, was assessed using a structured interview. High brachial-ankle pulse wave velocity (baPWV), a marker of arterial stiffness, was defined as the highest gender-specific quartile of maximal baPWV distribution in the study population.
RESULTS
Compared to never drinkers, the multivariate-adjusted odds ratio (OR) of men who consumed 0.1-10.0, 10.1-20.0, 20.1-40.0, and >40.0 g/day was 0.93, 1.18, 1.38, and 2.36, respectively. The OR was 0.90, 0.97, 1.45, and 1.82 in women consuming 0.1-5.0, 5.1-10.0, 10.1-20.0, and >20.0 g/day, respectively. Binge drinking of <1 day/week (OR=1.66, 95% confidence interval [CI]=1.13-2.42) and > or =1 day/week (OR=1.61, 95% CI=1.04-2.50) were associated with increased risk for high baPWV in men, and binge drinking of > or =1 day/week (OR=3.12, 95% CI=1.16-8.34) was associated with increased risk for high baPWV in women.
CONCLUSIONS
A J-shaped relationship between the average volume of alcohol consumption and high baPWV was observed, suggesting the detrimental effects of heavy alcohol drinking on arterial stiffness. Binge drinking was also significant risk factors for increased arterial stiffness, independently of the average volume of alcohol consumption.

Keyword

Alcohol drinking; Atherosclerosis; Peripheral arterial diseases

MeSH Terms

Adult
Aged
Alcohol Drinking
Atherosclerosis
Binge Drinking
Female
Humans
Male
Odds Ratio
Peripheral Arterial Disease
Pulse Wave Analysis
Risk Factors
Vascular Stiffness