Korean J Physiol Pharmacol.  2014 Oct;18(5):359-363. 10.4196/kjpp.2014.18.5.359.

MicroRNA-1 in Cardiac Diseases and Cancers

Affiliations
  • 1Department of Pharmacy, Ruikang Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi 530011, China.
  • 2Department of Osteology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China.
  • 3Department of Physiology and pathophysiology, school of Basic Medical Sciences, Jiujiang University, Jiujiang, Jiangxi 332000, China.
  • 4Department of Pharmacy, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China. wujianhua122012@126.com

Abstract

MicroRNAs (miRs) are endogenous approximately22-nt non-coding RNAs that participate in the regulation of gene expression at post-transcriptional level. MiR-1 is one of the muscle-specific miRs, aberrant expression of miR-1 plays important roles in many physiological and pathological processes. In this review, we focus on the recent studies about miR-1 in cardiac diseases and cancers. The findings indicate that miR-1 may be a novel, important biomarker, and a potential therapeutic target in cardiac diseases and cancers.

Keyword

Cancers; Cardiac diseases; MicroRNA-1

MeSH Terms

Gene Expression Regulation
Heart Diseases*
MicroRNAs
Pathologic Processes
RNA, Untranslated
MicroRNAs
RNA, Untranslated
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