Intest Res.  2011 Dec;9(3):225-229. 10.5217/ir.2011.9.3.225.

A Case of Pyoderma Gangrenosum of the Face Associated with Ulcerative Colitis

• Kim ES
• Seo MH
• Choi HS
• Keum B
• Seo YS
• Kim YS
• Jeen YT
• Lee HS
• Chun HJ
• Um SH
• Kim CD
• Ryu HS

• KMID: 2284951
• DOI: http://doi.org/10.5217/ir.2011.9.3.225

Abstract

Ulcerative colitis is associated with various extra-intestinal manifestations, including rheumatic, dermatologic, ophthalmologic, biliary, and hematologic manifestations. Cutaneous findings are common extra-intestinal manifestations of ulcerative colitis, occurring in 10-20% of patients. Cutaneous manifestations include erythema nodosum, pyoderma gangrenosum, aphthous stomatitis, and acute febrile neutrophilic dermatosis. Treatments for these cutaneous manifestations include corticosteroids, cyclosporine, tacrolimus, mycophenolate mofetil, azathioprine, and infliximab. A 48-year-old male presented with an acute exacerbation of ulcerative colitis associated with multiple skin lesions on his face, thumbs, thighs, and feet. The final impression was neutrophilic folliculitis, which is an early form of pyoderma gangrenosum. The patient's skin lesions and colitis both improved with corticosteroids. There are rare published case reports of ulcerative colitis exacerbations associated with pyoderma gangrenosum that initiated as neutrophilic folliculitis of the face. This case report includes a review of the literature.

Keyword

Colitis; Ulcerative; Skin Manifestations; Pyoderma Gangrenosum

MeSH Terms

Adrenal Cortex Hormones
Antibodies, Monoclonal
Azathioprine
Colitis
Colitis, Ulcerative
Cyclosporine
Erythema Nodosum
Folliculitis
Foot
Humans
Infliximab
Male
Middle Aged
Mycophenolic Acid
Neutrophils
Pyoderma
Pyoderma Gangrenosum
Skin
Skin Manifestations
Stomatitis, Aphthous
Sweet Syndrome
Tacrolimus
Thigh
Thumb
Ulcer
Adrenal Cortex Hormones
Antibodies, Monoclonal
Azathioprine
Cyclosporine
Mycophenolic Acid
Tacrolimus