Korean J Pediatr.
2013 May;56(5):191-195. 10.3345/kjp.2013.56.5.191.
Phenotypes and endotypes of severe asthma in children
- Affiliations
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- 1Department of Pediatrics, Allergy Immunology Center, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea. yoolina@korea.ac.kr
- KMID: 2284834
- DOI: http://doi.org/10.3345/kjp.2013.56.5.191
Abstract
- Severe childhood asthma is a complicated and heterogeneous disorder with distinct phenotypes. Children with severe asthma have more persistent symptoms despite receiving treatment, more atopy, greater airway obstruction, and more air trapping than those with mild-to-moderate asthma. They also have higher morbidity and substantial airflow limitations that persist throughout adulthood. Identification of the phenotype clusters and endotypes of severe asthma can allow further modulation of the natural history of severe asthma and may provide the pathophysiologic rationale for appropriate management strategies.
