Exp Neurobiol.  2013 Dec;22(4):337-340. 10.5607/en.2013.22.4.337.

Anti-LGI1 Limbic Encephalitis Presented with Atypical Manifestations

• Lee JJ
• Lee ST
• Jung KH
• Chu K
• Lee SK

• KMID: 2284638
• DOI: http://doi.org/10.5607/en.2013.22.4.337

Abstract

Anti-leucine-rich glioma inactivated-1 (LGI1) limbic encephalitis (LE) is a rare neurological disorder that has a subacute course of progressive encephalopathy and fasciobrachial dystonic seizures. We report a patient with anti-LGI1 LE that presented with atypical manifestations that complicated the diagnosis. A 62-year-old woman presented with a chronic course of memory disturbance and a subsequent relapse with an altered mental status after 10 months. The patient reported frequent chest pain of squeezing and dull nature, typically lasting 10-30 seconds. The chest pain was related to partial seizures, which were confirmed by video-EEG monitoring. Anti-LGI1 antibody was identified in serum and CSF. The patient's symptoms improved by immune modulation treatment. Patients with anti-LGI1 LE can experience atypical partial seizures, and a chronic relapsing course. Clinical suspicions and video-EEG monitoring are helpful for the early diagnosis and effective immune modulation.

Keyword

limbic encephalitis; chest pain; seizure; immune

MeSH Terms

Chest Pain
Diagnosis
Early Diagnosis
Female
Glioma
Humans
Limbic Encephalitis*
Memory
Middle Aged
Nervous System Diseases
Recurrence
Seizures