Korean J Pediatr.
2015 Sep;58(9):330-335. 10.3345/kjp.2015.58.9.330.
Food allergen sensitization in young children with typical signs and symptoms of immediate-type food allergies: a comparison between monosensitized and polysensitized children
- Affiliations
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- 1Department of Pediatrics, CHA Bundang Medical Center, Seongnam, Korea.
- 2Department of Pediatrics, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea.
- 3Department of Pediatrics, Myongji Hospital, Goyang, Korea.
- 4Department of Pediatrics, CHA University School of Medicine, Pocheon, Korea. epirubicin13@gmail.com
- 5Department of Pediatrics, Hallym University Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
- 6Department of Pediatrics, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea.
- 7Department of Pediatrics, CHA Gangnam Medical Center, Seoul, Korea.
- 8Department of Medicine, The Graduate School, Yonsei University, Seoul, Korea.
- 9Department of Pediatrics, Seoul Medical Center, Seoul, Korea.
- 10Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
- KMID: 2284513
- DOI: http://doi.org/10.3345/kjp.2015.58.9.330
Abstract
- PURPOSE
The clinical interpretation of children sensitized to allergens is challenging, particularly in children with food allergies. We aimed to examine clinical differences between children with monosensitization and those with polysensitization to common food allergens and to determine risk factors for polysensitization in young children <10 years of age with immediate-type food allergies.
METHODS
The study included children <10 years of age with signs and symptoms indicative of immediate-type food allergies. Serum total IgE level was measured, and ImmunoCAP analysis for food allergens was performed.
RESULTS
The mean age of the study subjects was 1.6+/-1.6 years (75 boys and 51 girls). Thirty-eight children (30.2%) were monosensitized and 88 children (69.8%) were polysensitized. Multivariate logistic regression analysis showed that the development of polysensitization to common food allergens was positively associated with a parental history of allergic rhinitis (adjusted odds ratio [aOR], 6.28; 95% confidence interval [CI], 1.78-22.13; P=0.004), season of birth (summer/fall) (aOR, 3.10; 95% CI, 1.10-8.79; P=0.033), and exclusive breastfeeding in the first 6 months of age (aOR, 3.51; 95% CI, 1.20-10.25; P=0.022).
CONCLUSION
We found significant clinical differences between children with monosensitization and those with polysensitization to common food allergens and identified risk factors for the development of polysensitization in young children with immediate-type food allergies. Clinicians should consider these clinical risk factors when evaluating, counseling, treating, and monitoring young children with food allergies.
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