Korean J Pediatr.  2013 Jul;56(7):286-290. 10.3345/kjp.2013.56.7.286.

Antibody response to pneumococcal vaccination in children with chronic or recurrent rhinosinusitis

• Baek JH
• Seo HK
• Jee HM
• Shin YH
• Han MY
• Oh ES
• Lee HJ
• Kim KH

• KMID: 2284255
• DOI: http://doi.org/10.3345/kjp.2013.56.7.286

Abstract

PURPOSE
Although chronic and recurrent rhinosinusitis is prevalent in children, little is known about its causes. Here, we investigated the humoral immunity in children with chronic or recurrent rhinosinusitis.
METHODS
We examined 16 children attending the outpatient clinic at the CHA Bundang Medical Center including 11 boys and 5 girls, aged 3.11 years (mean age, 5.6 years), who had rhinosinusitis for >3 months or >3 times per year. The complete blood count with differential and total serum concentrations of Immunoglobulin (Ig) E, IgA, IgD, IgM, IgG, and IgG subclasses (IgG1, IgG2, IgG3, and IgG4) of all children were measured. All subjects received 23-polysaccharide pneumococcal vaccination (PPV), and the levels of antibodies to 5 serologic types (4, 6B, 14, 18C, and 23F) of pneumococcal capsular polysaccharide antigens were measured before and after vaccination. Post-PPV antibody titers > or =0.35 microg/mL or with a > or =4-fold increase were considered as positive responses.
RESULTS
The titers of IgG, IgA, IgD, and IgM were within normal range in all 16 children, whereas the total IgE concentration was higher than normal in 2 children. IgG1 deficiency was observed in 1 patient and IgG3 deficiency in 3. After PPV, 1 patient failed to respond to all 5 serologic types, 2 failed to respond to 4 serologic types, and 2 failed to respond to 3 serologic types.
CONCLUSION
Clinicians should consider the evaluation of humoral immune functions in children with chronic or recurrent rhinosinusitis who do not respond to prolonged antibiotic treatment.

Keyword

Rhinosinusitis; Humoral immune deficiency; Polysaccharide pneumococcal vaccines

MeSH Terms

Aged
Ambulatory Care Facilities
Antibodies
Antibody Formation
Blood Cell Count
Child
Humans
Immunity, Humoral
Immunoglobulin A
Immunoglobulin D
Immunoglobulin E
Immunoglobulin G
Immunoglobulin M
Immunoglobulins
Reference Values
Vaccination
Antibodies
Immunoglobulin A
Immunoglobulin D
Immunoglobulin E
Immunoglobulin G
Immunoglobulin M
Immunoglobulins