Korean J Phys Anthropol.  1999 Dec;12(2):289-296.

An Analysis of HRV Spectrum for Observing ANS Variations Caused by Sympathectomy and Vagotomy

Affiliations
  • 1Samsung Biomedical Research Institute, Korea.
  • 2Department of Bionics, Chonbuk National University, Korea.
  • 3Department of Anatomy, College of Medicine, Inje University, Korea.

Abstract

Increased death rate resulted from cardiovascular disease called for the study on the autonomic nervous system and cardiovascular system. It is known that an HRV (heart rate variability) spectrum analysis based on ECG (electrocardiograph) signals could be used to define activity of sympathetic and parasympathetic nervous system noninvasively. However, it is important to prove whether suggested HRV analysis method could provide the useful information for observing autonomic nervous system quantitatively and objectively before clinical application. In this study, 14 rats were used and divided into two groups, sympathectomy group and vagotomy group, respectively. During the experiment, ECGs of rats were collected three times at each experimental condition. After the application of Berger's series algorithm to the ECG raw data, HRV spectrum was obtained via FFT (fast Fourier transform). Power contents for each frequency bands were calculated from HRV waveforms. Two peak values, HF (high frequency) and LF(low frequency), representing autonomic nervous system status were used to extract the parameter, HF/LF ratio. Results showed that HF/LF values were increased for the sympathectomy group and decreased for the vagotomy group. It implies that the variations in HF/LF components exhibits the information for the classification of ANS(autonomic nervous system) function quantitatively. HRV analysis algorithm developed from this study could be expanded for the observation of autonomic nervous system variations in human.

Keyword

Autonomic nervous system; HRV spectrum; Sympathectomy; Vagotomy; ECG

MeSH Terms

Animals
Autonomic Nervous System
Cardiovascular Diseases
Cardiovascular System
Classification
Electrocardiography
Humans
Mortality
Parasympathetic Nervous System
Rats
Spectrum Analysis
Sympathectomy*
Vagotomy*
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