Effect of Drinking and Smoking on AST and ALT Activities

Kim, Doohie; Seo, Seol

Abstract

The study is carried out to investigate the effect of drinking and smoking for the activities of aspartate aminotransferse(AST, or GOT) and alanine amintransferse(ALT or GPT), from December 25, 1986 to April 30, 1987. The male physical examinees for employment, 900 who had visited to the Taegu Medical Center were subjected. And the positive cases of HBs-Ag, Anti-HBs and skin test for Clonorchis sinensis were excluded. The general characters of drinking and smoking pattern were introduced by interview with questionnaire provided for. In drinking cases, the longer duration was significantly effected the higher rate of abnormality in AST and ALT level. But the amount and the frequency were not. It was not appeared effects by mackgulri which is a Korean traditional wine and small amount of beers. In smoking cases, also same pattern. The age was related in all cases. By the way, when the effect is related the positive results with other factors; HBs-Ag, Anti-HBs, skin test for clonorchiasis and harmful occupational history, it is higher abnormal rate of AST and ALT in the duplicated cases with two factors or more. Particularly in HBs-Ag positive cases, those who had smoking was the highest in rate of abnormality, and drinking was the follows. In correlation matrix among seven factors; HBs-Ag, age, drinking amount, drinking period, drinking frequency, smoking amount and smoking period, correlation coefficient was significant between the abnormal rate and to with age, drinking period, smoking period, and smoking amount.