Tuberc Respir Dis.  1990 Sep;37(3):288-293. 10.4046/trd.1990.37.3.288.

Relationship between Changes of the Value of s-AST/ALT and Serologic Markers for Hepatitis B Virus during Anti-tuberculosis (HRE) Treatment

• KMID: 2528484
• DOI: http://doi.org/10.4046/trd.1990.37.3.288

Abstract

A clinical study was performed in 272 patients who had pulmonary tuberculosis to evaluate the relationship between changes of the value of s.AST / ALT and serologic markers for hepatitis B virus during anti-tuberculous treatment with three drug regimen of isoniazid (INH), rifampicin (RFP), and ethambutol (EMB).
Results
were as follows: 1) Among the 272 pulmonary tuberculosis patients, 54 patients had HBsAg (+), 82 patients had HBsAb (+), and 136 patients had HBsAg (-) & HBsAb (-). 2) During the antituberculous chemotherapy, s.AST/ALT were elevated in 48 (17.6%) patients. Among the 54 patients with HBsAg, 10 patients (18.5%) showed elevation of s.AST/ ALT; among 83 patients with HBsAb, 13 patients (15.9%) showed s.AST/ ALT elevation; and among 136 patients without HBsAg & HBsAb, 25 patients (18.4%) showed s.AST/ ALT elevation. 3) There was no statistical significance between the time and degree of s.AST/ ALT elevation. 4) Treatment interruption occurred in 2 patients due to the marked elevation of s.AST/ ALT . One patient was HBsAg.positive and the other was negative in HBsAg & HBsAb. As a result of this study, we concluded that the relationship between changes of the value of s-AST / ALT and serologic markers for hepatitis B virus was not significantly different among each group of patients with HBsAg, HBsAb, and without HBsAg & HBsAb during antituberculous treatment with isoniazid, rifampicin, and ethamutol (HRE) regimen.