Endocrinol Metab.  2015 Jun;30(2):201-207. 10.3803/EnM.2015.30.2.201.

Associations between Dietary Acid-Base Load and Cardiometabolic Risk Factors in Adults: The Tehran Lipid and Glucose Study

• Bahadoran
• Mirmiran P
• Khosravi H
• Azizi F

• KMID: 2282011
• DOI: http://doi.org/10.3803/EnM.2015.30.2.201

Abstract

BACKGROUND
In this study we investigated the associations of dietary acid-base load, identified by potential renal acid load (PRAL) and protein to potassium (Pro:K) ratio, with cardiometabolic risk factors in Tehranian adults.
METHODS
A cross-sectional study was conducted within the framework of the fourth phase of the Tehran Lipid and Glucose Study (2009 to 2011) on 5,620 men and women aged 19 to 70 years. Dietary data were collected by a trained dietitian using a validated, 147-food item, semi-quantitative food frequency questionnaire, and dietary PRAL and Pro:K ratio were calculated. Multiple linear regression models with adjustment for potential confounding variables were used to evaluate the associations of dietary acid-base load with anthropometric measures, blood pressure, serum triglycerides, high density lipoprotein cholesterol (HDL-C), serum creatinine, and fasting blood glucose.
RESULTS
The mean+/-SD age of the participants was 39.8+/-12.8 years and 54% of participants were women. Mean+/-SD PRAL was -22.0+/-29.1; mean PRAL was -15.6 in men and -26.8 in women. Dietary PRAL was associated with weight (beta=0.098, P<0.001), waist circumference (beta=0.062, P<0.01), serum triglycerides (beta=0.143, P<0.01), HDL-C (beta=-0.11, P<0.01), diastolic blood pressure (beta=0.062, P<0.01), and serum creatinine (beta=0.142, P<0.001). Pro:K ratio was associated with weight (beta=0.055, P<0.001), waist circumference (beta=0.04, P<0.01), serum HDL-C (beta=-0.06, P<0.01), serum triglycerides (beta=0.03, P<0.05), diastolic blood pressure (beta=0.026, P<0.05), and serum creatinine (beta=0.07, P<0.01).
CONCLUSION
A more acidic dietary acid-base load may be a risk factor for the development of metabolic disorders.

Keyword

Dietary acid-base load; Potential renal acid load; Protein to potassium ratio; Cardiometabolic risk factors

MeSH Terms

Adult*
Blood Glucose
Blood Pressure
Cholesterol, HDL
Confounding Factors (Epidemiology)
Creatinine
Cross-Sectional Studies
Fasting
Female
Glucose*
Humans
Linear Models
Male
Nutritionists
Potassium
Risk Factors*
Triglycerides
Waist Circumference
Surveys and Questionnaires
Blood Glucose
Cholesterol, HDL
Creatinine
Glucose
Potassium
Triglycerides

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