Korean J Pediatr.  2009 Apr;52(4):508-511. 10.3345/kjp.2009.52.4.508.

A case of fatal pneumococcal 19A meningoencephalitis despite administration of seven-valent pneumococcal conjugate vaccines

Affiliations
  • 1Department of Pediatrics, Masan Samsung Hospital, Sungkyunkwan University School of Medicine, Masan, Korea. ljh3643@skku.edu

Abstract

Streptococcus pneumoniae is a major cause of serious invasive diseases in children, especially in young infants, but seven-valent pneumococcal conjugate vaccine (PCV7) is believed to prevent invasive pneumococcal pneumonia and meningitis in young children. However, recently, the incidence of non-PCV7 serotype has increased after PCV7 vaccination. A 14-month-old female patient presented at our emergency room with mental change and lethargy. Three days previously, she had developed fever and vomiting. After being admitted, she rapidly progressed to coma and brain death despite prompt and extensive supportive treatment. She expired 20 days after admission with a final diagnosis of pneumococcal 19A (non-PCV7 serotype) meningoencephalitis despite having received PCV7 (Prevenar(R)) vaccinations on three occasions. The author reports this first fatality due to pneumococcal 19A meningoencephalitis in Korea and provides a brief review of the literature.

Keyword

Streptococcus Pneumonia Infections; Meningoencephalitis; Serotype 19A

MeSH Terms

Brain Death
Child
Coma
Emergencies
Female
Fever
Humans
Incidence
Infant
Korea
Lethargy
Meningitis
Meningoencephalitis
Pneumonia, Pneumococcal
Streptococcus pneumoniae
Vaccination
Vaccines, Conjugate
Vomiting
Vaccines, Conjugate
Full Text Links
  • KJP
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr