Korean J Pediatr.
2009 Apr;52(4):504-507. 10.3345/kjp.2009.52.4.504.
Autoimmune hepatitis-primary sclerosing cholangitis overlap syndrome in a 10-year-old girl with ulcerative colitis
- Affiliations
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- 1Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea. jkseo@snu.ac.kr
- 2Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
- 3Department of Radiology, Seoul National University College of Medicine, Seoul, Korea.
- KMID: 2281754
- DOI: http://doi.org/10.3345/kjp.2009.52.4.504
Abstract
- Autoimmune hepatitis (AIH), primary sclerosing cholangitis (PSC), and primary biliary cirrhosis (PBC) are chronic autoimmune liver diseases. Overlap syndrome is defined as a condition in which the clinical, biochemical, and histological features of these autoimmune diseases are overlapped. Thus, it is difficult to appreciate overlap syndrome as an actual diagnostic entity. Only a few cases of the overlap syndrome of AIH and PSC have been reported, especially in children. Moreover, PSC is known to be the most frequent liver disorder associated with inflammatory bowel diseases such as ulcerative colitis. We report one case of AIH-PSC overlap syndrome in a child who was diagnosed as having ulcerative colitis.
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