Korean J Pediatr.  2010 Sep;53(9):859-862. 10.3345/kjp.2010.53.9.859.

Transient splenial lesion of the corpus callosum in a case of benign convulsion associated with rotaviral gastroenteritis

• Jang YY
• Lee KH

• KMID: 2281282
• DOI: http://doi.org/10.3345/kjp.2010.53.9.859

Abstract

Transient magnetic resonance (MR) signal changes in the splenium of the corpus callosum (SCC) arise from many different conditions, including encephalopathy or encephalitis caused by infection, seizures, metabolic derangements, and asphyxia. Few case reports exist on reversible SCC lesions associated with rotavirus infection. A benign convulsion with mild gastroenteritis (CwG) is frequently associated with rotaviral infections. This entity is characterized by normal laboratory findings, electroencephalogram, neuroimaging, and good prognosis. We report a case of a 2.5-year-old Korean girl with rotavirus-associated CwG demonstrating a reversible SCC lesion on diffusion-weighted MR images. She developed 2 episodes of brief generalized tonic-clonic seizure with mild acute gastroenteritis without any other neurologic abnormality. Stool test for rotavirus antigen was positive. Brain MRI done on the day of admission showed a linear high signal intensity and decreased apparent diffusion coefficient values on the SCC. The lesion completely disappeared on follow-up MRI 6 days later. The patient fully recovered without any sequelae.

Keyword

Corpus callosum; Magnetic resonance imaging; Diffusion; Rotavirus infection; Seizures; Child

MeSH Terms

Asphyxia
Brain
Child
Corpus Callosum
Diffusion
Electroencephalography
Encephalitis
Follow-Up Studies
Gastroenteritis
Humans
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Neuroimaging
Prognosis
Rotavirus
Rotavirus Infections
Seizures