Korean J Pediatr.  2009 Sep;52(9):984-990. 10.3345/kjp.2009.52.9.984.

Catch up growth in children born small for gestational age by corrected growth curve

• Jung MK
• Song JE
• Yang S
• Hwang IT
• Lee HR

• KMID: 2281253
• DOI: http://doi.org/10.3345/kjp.2009.52.9.984

Abstract

PURPOSE
Being small for gestational age (SGA) is a risk factor of short stature in children. Genetic background such as mid-parental height (MPH) is known to influence growth of children born SGA. We studied the relationship between growth of children born SGA and MPH and studied the effects of insulin-like growth factor (IGF-I) and insulin-like growth factor binding protein 3 (IGFBP-3) on postnatal growth in children born SGA according to MPH.
METHODS
Forty-nine neonates born SGA were included in this study. We defined corrected height standard deviation score (cHtSDS) by modified height SDS (HtSDS) based on their MPH. We categorized subjects into group 1 consisting of children with cHtSDS > or =0 (n=35) and group 2 consisting of children with cHtSDS <0 (n=14), and compared IGF-I and IGFBP-3 between the two groups.
RESULTS
The HtSDSs and cHtSDSs in groups 1 and 2 were 0.06+/-1.05 vs. -0.95+/-0.85 (P=0.000) and 0.78+/-0.93 vs. -0.46+/-0.67 (P=0.000), respectively. IGF-I SDS was higher in group 1 than in group 2 (2.82+/-3.69 vs. 0.23+/-2.42, P=0.012). Total cHtSDS (0.42+/-1.03) was significantly higher than HtSDS (-0.22+/-1.10) (P=0.000).
CONCLUSION
Our results show that cHtSDS differs significantly from HtSDS. Growth assessment by standardized growth curve does not uniformly show effects of genetic factors. A more accurate assessment of growth uses a personalized corrected growth curve that considers the genetic factor measured by MPH.

Keyword

Small for gestational age; Insulin-like growth factor; Insulin-like growth factor binding protein 3; Catch up growth

MeSH Terms

Child
Gestational Age
Humans
Infant, Newborn
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Phenazines
Risk Factors
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Phenazines