Korean J Pediatr.  2009 Mar;52(3):376-379. 10.3345/kjp.2009.52.3.376.

Pseudohypoaldosteronism in a premature neonate with severe polyhydramnios in utero

• Ahn SY
• Shin SM
• Kim KA
• Lee YK
• Ko SY

• KMID: 2281118
• DOI: http://doi.org/10.3345/kjp.2009.52.3.376

Abstract

We report a case of a premature newborn baby who presented with hyponatremia, hyperkalemia, and metabolic acidosis accompanied by severe polyhydramnios in utero. The baby was diagnosed with pseudohypoaldosteronism on the basis of normal 17-hydroxyprogesterone levels, elevated aldosterone, and clinical symptoms. His serum electrolyte levels were corrected with sodium chloride supplementation. Sodium supplementation was reduced gradually and discontinued at 5 months of age. At 5 months, the child was able to maintain normal serum electrolyte levels without oral sodium chloride supplementation, and showed normal physical and neurological development. This case illustrates that pseudohypoaldosteronism must be considered if a newborn infant with an antenatal history of severe polyhydramnios shows excessive salt loss with normal levels of 17-hydroxyprogesterone.

Keyword

Pseudohypoaldosteronism; Polyhydramnios

MeSH Terms

17-alpha-Hydroxyprogesterone
Acidosis
Aldosterone
Child
Humans
Hyperkalemia
Hyponatremia
Infant, Newborn
Polyhydramnios
Pseudohypoaldosteronism
Sodium
Sodium Chloride
17-alpha-Hydroxyprogesterone
Aldosterone
Sodium
Sodium Chloride