Korean J Pediatr.
2009 Mar;52(3):324-329. 10.3345/kjp.2009.52.3.324.
Nationwide surveillance of acute interstitial pneumonia in Korea
- Affiliations
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- 1Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. sjhong@amc.seoul.kr
- 2Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
- 3Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
- 4Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- 5Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea.
- 6Korea Centers for Disease Control and Prevention, Seoul, Korea.
- KMID: 2281110
- DOI: http://doi.org/10.3345/kjp.2009.52.3.324
Abstract
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PURPOSE: Acute interstitial pneumonia (AIP) is a rare disease, but its prognosis is fatal because of lack of efficient treatment modality. Recently, it has been reported that there was epidemic AIP in Korea. This study aims to investigate the past and current status of AIP in Korea.
METHODS
We performed a nationwide survey and a prospective study. From August 6 to 15, 2008, a questionnaire survey was conducted to identify the prevalence, local distribution, and response to current treatments. The questionnaire was answered by pediatrician working in 23 referral centers in Korea. In addition, 5 referral centers in Seoul performed a preliminary prospective observational study by obtaining clinical data and specimens from appropriate patients. The Korea Centers for Disease Control and Prevention analyzed the samples for possible pathogens.
RESULTS
The survey showed 78 AIP cases had occurred and 36 patients had died. Lung biopsy was performed only on 20 patients. In 2008, 9 AIP cases developed. In a prospective study, 9 (M:F=5:4) patients developed AIP in spring and 7 (78%) died, with the mean rate of death occurring 46 days after diagnosis. Human corona virus 229 E, cytomegalovirus, influenza A virus, influenza B virus, and parainfluenza virus were isolated from the respiratory specimens.
CONCLUSION
This study showed nationwide prevalence of AIP in Korea. In addition, because of the high mortality rate and rapid progress, pediatricians need to be aware of the disease. Further studies and a nationwide network are required for reducing the morbidity and mortality rates related to AIP.
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