Diabetes Metab J.  2013 Feb;37(1):72-80. 10.4093/dmj.2013.37.1.72.

Predictive Clinical Parameters and Glycemic Efficacy of Vildagliptin Treatment in Korean Subjects with Type 2 Diabetes

• Chang JS
• Shin J
• Kim HS
• Kim KH
• Shin JA
• Yoon KH
• Cha BY
• Son HY
• Cho JH

• KMID: 2280745
• DOI: http://doi.org/10.4093/dmj.2013.37.1.72

Abstract

BACKGROUND
The aims of this study are to investigate the glycemic efficacy and predictive parameters of vildagliptin therapy in Korean subjects with type 2 diabetes.
METHODS
In this retrospective study, we retrieved data for subjects who were on twice-daily 50 mg vildagliptin for at least 6 months, and classified the subjects into five treatment groups. In three of the groups, we added vildagliptin to their existing medication regimen; in the other two groups, we replaced one of their existing medications with vildagliptin. We then analyzed the changes in glucose parameters and clinical characteristics.
RESULTS
Ultimately, 327 subjects were analyzed in this study. Vildagliptin significantly improved hemoglobin A1c (HbA1c) levels over 6 months. The changes in HbA1c levels (DeltaHbA1c) at month 6 were -2.24% (P=0.000), -0.77% (P=0.000), -0.80% (P=0.001), -0.61% (P=0.000), and -0.34% (P=0.025) for groups 1, 2, 3, 4, and 5, respectively, with significance. We also found significant decrements in fasting plasma glucose levels in groups 1, 2, 3, and 4 (P<0.05). Of the variables, initial HbA1c levels (P=0.032) and history of sulfonylurea use (P=0.026) were independently associated with responsiveness to vildagliptin treatment.
CONCLUSION
Vildagliptin was effective when it was used in subjects with poor glycemic control. It controlled fasting plasma glucose levels as well as sulfonylurea treatment in Korean type 2 diabetic subjects.

Keyword

Diabetes mellitus; Dipeptidyl peptidase 4; Dipeptidyl peptidase 4 inhibitor; Vildagliptin

MeSH Terms

Adamantane
Diabetes Mellitus
Dipeptidyl Peptidase 4
Fasting
Glucose
Hemoglobins
Nitriles
Plasma
Pyrrolidines
Retrospective Studies
Adamantane
Dipeptidyl Peptidase 4
Glucose
Hemoglobins
Nitriles
Pyrrolidines

Figure

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  Fig. 1 Subject profiles.

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  Fig. 2 Mean change from baseline in (A) hemoglobin A1c (HbA1c), (B) fasting plasma glucose (FPG), and (C) postprandial glucose 2 hours (PP2) values by group. (A) All at 6 month: P<0.05. (B, C) At 6 month: aP<0.05.

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  Fig. 3 Mean changes (SEM) from baseline in hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), and postprandial glucose 2 hours (PP2) values according to baseline HbA1c subgroup were significant. (A) Change in HbA1c level according to baseline HbA1c level. (B) Changes in FPG level according to baseline HbA1c level. (C) Changes in PP2 level according to baseline HbA1c level.

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