Korean J Perinatol.  2005 Jun;16(2):146-153.

Clinical Analysis of 739 Cases of Midtrimester Amniocentesis

• Chun YY
• Ku JY
• Song JW
• Kim BS
• Bae YY
• Sun JG
• Kee KS

Abstract

OBJECTIVE
To analyze the change of indications and chromosomal abnormalities according to patient's age and indications in midtrimester genetic amniocentesis.
METHODS
This study was reviewed 739 genetic amniocentesis results which were performed at Kwangju Christian Hospital from 1995 to 2004, as prenatal genetic diagnosis for the possibility of chromosomal abnormality of fetus. Age distribution, gestational weeks, indications of amniocentesis and cytogenetic results were the key factors for the analysis.
RESULTS
Maternal ages were ranged from 25 to 45, mostly 25~39, Of indications of prenatal genetic amniocentesis, abnormal maternal serum marker was the most common (49.8%), and followed by advanced maternal age (31.1%). The frequency of abnormal karyotypes was 4.6% (34/739). The incidence of abnormal karyotype according to indication had statistical significance in abnormal ultrasonographic finding.
CONCLUSION
Among the several indications for prenatal cytogenetic diagnosis, ultrasonographic abnormalities and abnormal maternal serum markers might be important indications. Especially, ultrasonographic abnormalities could be the predictive markers for abnormal fetal karyotypes.

Keyword

Genetic amniocentesis; Chromosomal abnormality; Prenatal diagnosis

MeSH Terms

Abnormal Karyotype
Age Distribution
Amniocentesis*
Biomarkers
Chromosome Aberrations
Cytogenetics
Diagnosis
Female
Fetus
Gwangju
Humans
Incidence
Karyotype
Maternal Age
Pregnancy
Pregnancy Trimester, Second*
Prenatal Diagnosis