Korean J Obstet Gynecol.  2003 Nov;46(11):2203-2208.

Clinical Analysis of 896 Cases of Midtrimester Amniocentesis

• Lee HA
• Choi SJ
• Chung IB
• Cha DS
• Han KH
• Kim HE
• Yoon KJ

Abstract

OBJECTIVE
We report our experience with midtrimester amniocentesis.
METHODS
This study was retrospectively reviewed 896 cases of midtrimester genetic amniocentesis from January 1997 to October 2003 in Yonsei university, Wonju Colleage of medicine. We analyzed the indications, distributions of gestational age, cytogenetic results, and the safety.
RESULTS
The most common Indications for amniocentesis were abnormal maternal serum marker (52.7%) and advanced maternal age (36.6%). Most amniocentesis has been performed during second trimester from 16 to 20 weeks. The incidence of chromosomal abnormality was 3.9% (35 cases). There were 26 cases of numerical aberration, 6 cases of structural aberration and 3 cases of mosaicism. In chromosomal aberration, there was 9.0% (2/22) of chromosomal abnormalities in abnormal ultrasonographic finding group and 6.9% (2/29) in previous chromosomal anomaly. There were 3 cases of fetal loss (0.3%) after amniocentesis.
CONCLUSION
Midtrimester amniocentesis is a useful and safe technique for the prenatal detection of genetic disorder.

Keyword

Amniocentesis; Chromosomal abnormality

MeSH Terms

Amniocentesis*
Biomarkers
Chromosome Aberrations
Cytogenetics
Female
Gangwon-do
Gestational Age
Humans
Incidence
Maternal Age
Mosaicism
Pregnancy
Pregnancy Trimester, Second*
Retrospective Studies