Korean J Obstet Gynecol.
2002 Jun;45(6):1040-1044.
Cytogenetic Aberration Analysis of Midtrimester Amniotic Fluid
- Affiliations
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- 1Department of Obstertics and Gynecology of Gachon Medical College, Incheon.
- 2Department of clinical pathology of Gachon Medical College, Incheon.
Abstract
OBJECTIVE
To analyze cytogenetic results of prenatal genetic amniocentesis.
METHODS
From January 1997 to December 2000, We analyzed 1,390 cases of midtrimester amniocentesis which were done at Gil medical center of Gachon medical school according to its indications and maternal age.
RESULTS
Chromosomal aberrations were found in 88 cases (6.3%). Of all our chromosomal aberrations, 29 cases (2.1%) of normal variants and 59 cases (4.2%) of abnormal karyotypes were found. 37 cases of autosomal numerical abnormal karyotypes and 7 cases of sex chromosomal abnormal karyotypes were diagnosed. In abnormal karyotype group, the incidence was high after 40 years of maternal age and in abnormal ultrasound findings, but no such correlations were found in normal variant group.
CONCLUSION
In analysis of midtrimester amniocentesis, it would be better to analyze separately abnormal karyotype group and normal variant group.
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