Korean J Pediatr.
2006 Nov;49(11):1211-1215. 10.3345/kjp.2006.49.11.1211.
Short-term follow up of thyroid function after pediatric hematopoietic stem cell transplantation
- Affiliations
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- 1Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. chobinkr@catholic.ac.kr
- 2Department of Pediatrics, College of Medicine, Kyung Hee University, Seoul, Korea.
- 3Department of Pediatircs, College of Medicine, Chungnam National University, Daejeon, Korea.
- 4Department of Pediatrics, Busan Paik Hospital, College of Medicine, Inje University, Busan, Korea.
- KMID: 2280069
- DOI: http://doi.org/10.3345/kjp.2006.49.11.1211
Abstract
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PURPOSE: In this study, we analyzed the short term changes of thyroid function, incidence and risk factors of thyroid dysfunction soon after allogeneic hematopoietic stem cell transplantation (HSCT) in children.
METHODS
We enrolled 80 pediatric patients following allogeneic HSCT, at the Catholic HSCT center between January, 2004 and February, 2006. Serum TSH (thyroid stimulating hormone), total serum thyroxine and total serum triiodothyronine levels were systematically measured in 80 patients before the HSCT, and at 1 month, 6 months and 12 months after HSCT.
RESULTS
Thyroid function statistically decreased at 1 month after HSCT(P < 0.001). Thyroid dysfunction at 1 month was observed in 43 (54 percent) of 80 patients, 31 (39 percent) of whom presented with euthyroid sick syndrome (ETS). Thyroid dysfunction was normalized within 1 year after HSCT. In univariate analysis, malignant disease and the presence of acute graft-versus-host disease (grade > or = II) were risk factors for ETS (P=0.04, 0.01 respectively). In multivariate analysis, we could not detect an independent risk factor for ETS (P=0.19, 0.06 respectively).
CONCLUSION
The present study suggests that the incidence of thyroid dysfunction is high after allogeneic HSCT. Therefore, regular monitoring of thyroid hormone levels after HSCT is required.
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