Korean J Pediatr Infect Dis.  2013 Aug;20(2):63-70.

Increasing Rates of Community Associated Methicillin-Resistant Staphylococcus aureus in Children with Muscular-Skeletal Infections in Korea: A Single Center Experience from 2000 to 2012

• Park JH
• Lee TJ

Abstract

PURPOSE
This study aimed to explore how prevalent the community-related methicillin-resistant Staphylococcus aureus (CA-MRSA) was in children with muscular-skeletal infections.
METHODS
We retrospectively reviewed the medical records of patients of 18 years or under who were diagnosed with suppurative arthritis or osteomyelitis and S. aureus from September 2000 through August 2012 at the CHA Bundang Medical center.
RESULTS
Thirty-one cases of suppurative arthritis or osteomyelitis were identified. The patients were between 17 days old and 18 years old with an average age of 7. Eleven cases (33.5%) of suppurative arthritis and 16 cases (51.6%) of osteomyelitis were observed. Five cases were accompanied by the two diseases. Methicillin sensitive S. aureus (MSSA) was isolated in 25 cases (80.6%) and methicillin resistant S. aureus (MRSA) was isolated in 6 cases (19.4%). Multidrug resistant strains were not observed. MRSA was not found from 2000 through 2005. All patients were treated with antibiotics and the duration of antibiotics treatment was 26.4+/-12.7 days. Vancomycin was used as the initial antibiotic treatment in 4 cases (12.9%) and vancomycin was used as the definitive antibiotics in the 10 cases (32.3%).
CONCLUSIONS
The result of this study showed that methicillin resistance rate of S. aureus from muscular-skeletal infections was concentrated in the latter half of the 12 year period.

Keyword

Community-related methicillin-resistant Staphylococcus aureus; Invasive skeletal infection; Children

MeSH Terms

Anti-Bacterial Agents
Arthritis, Infectious
Child
Humans
Medical Records
Methicillin
Methicillin Resistance
Methicillin-Resistant Staphylococcus aureus
Osteomyelitis
Retrospective Studies
Vancomycin
Anti-Bacterial Agents
Methicillin
Vancomycin

Figure

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  Fig. 1. Site of involvement of osteomyelitis and suppu-ratieve arthritis.

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  Fig. 2. Cultured organisms stratified on the basis of age distribution. MSSA, methicillin-sensitive Staphylococcus aureus; MRSA, methicillin-resistant Staphylococcus aureus.

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  Fig. 3. Prevalence of MRSA and MSSA infection in children with invasive skeletal infections stratified on the basis of year. MSSA, methicillin-sensitive Staphylococcus aureus; MRSA, methicillin-resistant Staphylococcus aureus.

Reference

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