Korean J Pediatr.  2007 Jan;50(1):52-55. 10.3345/kjp.2007.50.1.52.

Clinical factors causing hyperbilirubinemia in patients with Kawasaki disease

• Moon KH
• Kim OR
• Yu ST
• Hong ME
• Lee CW
• Choi DY
• Oh YK
• Kim JD
• Yoon HS

• KMID: 2278747
• DOI: http://doi.org/10.3345/kjp.2007.50.1.52

Abstract

PURPOSE: Hyperbilirubinemia, jaundice and gallbladder hydrops are unusual manifestations of Kawasaki disease (KD). In this case, abdominal pain, anorexia and abdominal distension may follow eventfully. We reviewed the clinical and laboratory data to investigate the causative factors of hyperbilirubinemia in patients with KD.
METHODS
Two-hundred eighty two children diagnosed and hospitalized with KD were identified by searching patients' charts. Cases were included in the study if diagnosed between January 1997 and December 2004. We reviewed clinical data, age, sex, duration from the onset of fever to admission and duration from start of treatment to defervescence. Clinical and laboratory data were compared between normal (A) and hyperbilirubinemia (B) groups.
RESULTS
Thirteen patients (4.6 percent) showed hyperbilirubinemia. In the hyperbilirubinemia group, age and initial ALT value were higher than group A (P=0.003, 0.018 respectively). Duration from the onset of fever to admission and age were relative risk factors in hyperbilirubinemia (P=0.007, 0.003 respectively) in patients with KD.
CONCLUSION
Shorter duration from the onset of fever to admission and older age group were relative risk factors of hyperbilirubinemia in patients with KD.

Keyword

Kawasaki disease; Hyperbilirubinemia

MeSH Terms

Abdominal Pain
Anorexia
Child
Edema
Fever
Gallbladder
Humans
Hyperbilirubinemia*
Jaundice
Mucocutaneous Lymph Node Syndrome*
Risk Factors