Korean J Pediatr.  2007 Feb;50(2):157-162. 10.3345/kjp.2007.50.2.157.

A clinical study of child bacterial meningitis in Daejeon and Chungcheong area : 2001-2005

• Lee YJ
• Lee SJ
• Park HJ
• Lee YH
• Kang SY
• Kim YC
• Lee IK
• Lee KY
• Lee KS
• Kim WS

• KMID: 2278719
• DOI: http://doi.org/10.3345/kjp.2007.50.2.157

Abstract

PURPOSE: The purpose of this study was to analyze the epidemiology, causative organism, clinical manifestation and prognosis of bacterial meningitis for children after the introduction of Haemophilus influenzae type b (Hib) vaccine in Daejeon and Chungcheong area.
METHODS
We analyzed retrospectively 53 medical records who had been diagnosed with bacterial meningitis at 10 general or university hospitals in Daejeon and Chungcheong area. All patients aged 1 month-14 years admitted between January 2001 through December 2005.
RESULTS
During the 5-year study period, 40 of all cases were positive for bacterial growth. Of the 40 cases that were CSF culture-proven bacterial meningitis, Streptococcus peumoniae was the most common bacteria for 17 (32.1%) of all cases, followed by H. influenzae for 10 (18.9%), Neisseria meningitidis for 3 (5.7%). In this study, the most common clinical manifestation is fever, accompanied by all cases. CSF leukocyte count was more than 100/mm3 in 45 (84.1%) cases. CSF glucose concentration was less than 50 mg/dL in 42 (79.2%) cases and protein concentration was more than 45 mg/ dL in 49 (92.5%) cases. 45 of all cases made a recovery after treatment and were discharged. Most common complication after treatment is subdural effusion (19.0%) and hearing disturbance (9.4%).
CONCLUSION
The most common organism of culture-proven bacterial meningitis in the children beyond neonatal period was S. pneumoniae. Continued surveillance studies were demanded to know the altered incidence of bacterial meningitis, because we expect the incidence of S. pneumoniae meninigitis will be on the decrease after more active innoculation of pneumococcal protein conjugate vaccine.

Keyword

Meningitis; Bacterial; Child; Streptococcus pneumoniae; Haemophilus influenzae

MeSH Terms

Bacteria
Child*
Epidemiology
Fever
Glucose
Haemophilus influenzae
Haemophilus influenzae type b
Hearing
Hospitals, University
Humans
Incidence
Influenza, Human
Leukocyte Count
Medical Records
Meningitis
Meningitis, Bacterial*
Neisseria meningitidis
Pneumonia
Prognosis
Retrospective Studies
Streptococcus
Streptococcus pneumoniae
Subdural Effusion
Glucose