Korean J Pediatr.
2006 Mar;49(3):273-277. 10.3345/kjp.2006.49.3.273.
Reye syndrome after acute enteritis during the neonatal period
- Affiliations
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- 1Department of Pediatrics, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, seoul, Korea. hongjlee@hallym.ac.kr
- 2Department of Pediatrics, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul, Korea.
- 3Department of Pediatrics, Seoul Samsung Medical Center, College of Medicine, Sungkyunkwan University, Seoul, Korea.
- 4Department of Pediatrics, Wonju Christian Hospital, College of Medicine, Yonsei University, Wonju, Korea.
- KMID: 2278585
- DOI: http://doi.org/10.3345/kjp.2006.49.3.273
Abstract
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PURPOSE: The prevalence of Reye syndrome has decreased since late 1980's. But we report that recently there were concentrative attacks of Reye syndrome after acute enteritis during the neonatal period.
METHODS
Clinical symptoms and laboratory results(quantitative organic acid analysis, routine chemistry, arterial blood gas analysis, serum ammonia) of seven patients admitted at the Samsung Medical Center, Sanggye Paik Hospital, Wonju Christian Hospital and Chuncheon Sacred Heart Hospital, referred from Jan. 2005 to Apr. 2005, were analysed retrospectively. The major clinical symptoms were derived from the patients' clinical records sended with urine samples and quantification of organic acids were done with gas chromatography and mass spectrometry.
RESULTS
The mean age of seven cases is 18 days and the major preceding symptoms were gastrointestinal symptoms(vomiting, diarrhea, refusal to feeding). The major clinical symptoms were clouded conciousness, repiratory difficulty, vomiting, seizures, and diarrhea. One patient died; that patient's serum ammonia was twenty times higher than normal.
CONCLUSION
The seven patients were neonates. Reye syndrome has been known to be closely related with upper respiratory infections as a preceding disease and to internal use of aspirin, but in our study, the major preceding disease of the seven cases was gastrointestinal infection and none of these used aspirin.
