Korean J Pain.  2012 Jan;25(1):28-32. 10.3344/kjp.2012.25.1.28.

Efficacy of Glycopyrrolate in Primary Hyperhidrosis Patients

• Lee HH
• Kim DW
• Kim DW
• Kim C

• KMID: 2278112
• DOI: http://doi.org/10.3344/kjp.2012.25.1.28

Abstract

BACKGROUND
Primary hyperhidrosis is a disorder of excessive sweating, which shares several features with anxiety disorders and has a negative impact on a patient's quality of life. Oral glycopyrrolate is one of the treatments available. There are a few published studies on the use of glycopyrrolate given orally in the treatment of hyperhidrosis.
METHODS
Thies is study was a review of case notes in a series of 36 patients with primary hyperhidrosis. We made a comparison between the Keller's scale score of a pre-glycopyrrolate medication group and the Keller's scale score f a post-glycopyrrolate medication group. The Milanez de Campos score, Short Form_36 (SF-36) score, Beck Depression Inventory (BDI) score, Beck Anxiety Inventory (BAI) score, and autonomic nervous system (ANS) scale score were also compared between the two groups.
RESULTS
In the post-glycopyrrolate medication group, there were declines in Keller's scale, and Milanez de Campos scale score and BAI score (P < 0.001). In addition, there were increases in SF_36 score in the post-glycopyrrolate medication group (P = 0.03) However, no changes were seen in, BDI score and ANS score in the post-glycopyrrolate medication group (P < 0.001).
CONCLUSIONS
Glycopyrrolate is an effective initial method of treating primary hyperhidrosis that, reduces anxiety and improve patients' quality of life.

Keyword

anticholinergic agents; glycopyrrolate; primary hyperhidrosis

MeSH Terms

Anxiety
Anxiety Disorders
Autonomic Nervous System
Cholinergic Antagonists
Depression
Glycopyrrolate
Humans
Hyperhidrosis
Quality of Life
Sweat
Sweating
Cholinergic Antagonists
Glycopyrrolate

Figure

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  Fig. 1 Comparison of the Keller scale and the Milanez de Campo scale of Pre- and post-glycopyrrolate medication groups.

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  Fig. 2 Comparison of the beck depression inventory (BDI), beck anxiety inventory (BAI) & autonomic nervous system (ANS) scale of pre- and post-glycopyrrolate medication groups.

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  Fig. 3 Comparison of the total short form (SF) 36 score of Pre- and post-glycopyrrolate medication groups.

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