Korean J Pain.  2013 Jan;26(1):89-93. 10.3344/kjp.2013.26.1.89.

Effectiveness of Oral Glycopyrrolate Use in Compensatory Hyperhidrosis Patients

• Gong TK
• Kim DW

• KMID: 1779032
• DOI: http://doi.org/10.3344/kjp.2013.26.1.89

Abstract

Compensatory hyperhidrosis or reflex hyperhidrosis is the increase in sweating in the postoperative stage of thoracic sympathectomy or lumbar sympathectomy. It shares several features with anxiety disorders and has a negative impact on a patient's quality of life. Oralglycopyrrolate is one of the treatment options available. This study reviewed case notes in a series of 19 patients with compensatory hyperhidrosis. We made a comparison between the Milanez de Campos score of a pre-glycopyrrolate medication group and the Milanez de Campos score of a post-glycopyrrolate medication group. The Beck Depression Inventory (BDI) score, Beck Anxiety Inventory (BAI) score, and autonomic nervous system (ANS) scale score were also compared between the pre-medication and post-medication groups. In the post-glycopyrrolate medication group, there was decrease in the Milanez de Campos score, BAI score, and BDI score (P < 0.05). But no meaningful change was seen in the ANS score in the post-glycopyrrolate medication group (P > 0.05). Glycopyrrolate is an effective medication in the treatment of compensatory hyperhidrosis that, can alleviate anxiety and improve patients' quality of life.

Keyword

anticholinergic agents; compensatory hyperhidrosis; glycopyrrolate; sympathectomy

MeSH Terms

Anxiety
Anxiety Disorders
Autonomic Nervous System
Cholinergic Antagonists
Depression
Glycopyrrolate
Humans
Hyperhidrosis
Quality of Life
Reflex
Sweat
Sweating
Sympathectomy
Cholinergic Antagonists
Glycopyrrolate

Figure

• 

  Fig. 1 Comparison of the Milanez de campos scale and the autonomic nervous system (ANS) scale of pre- and post-glycopyrrolate medication groups. Milanez de campos scale show meaningful statistical significance, but ANS scale didn't.

• 

  Fig. 2 Comparison of the Modified beck depression inventory (M-BDI) and beck anxiety inventory (BAI) Scale of pre- and post-glycopyrrolate medication groups. Both scale show meaningful statistical significance.

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