Korean J Otorhinolaryngol-Head Neck Surg.  2015 May;58(5):318-323. 10.3342/kjorl-hns.2015.58.5.318.

Therapeutic Effect of Zinc and Lipoprostaglandin E1 for Idiopathic Sudden Hearing Loss

• Lee HY
• Kim JC
• Chang DS
• Choi MS
• Cho CS
• Kim AY

• KMID: 2277860
• DOI: http://doi.org/10.3342/kjorl-hns.2015.58.5.318

Abstract

BACKGROUND AND OBJECTIVES
We aimed to analyze the therapeutic effect of zinc, lipoprostaglandin E1 in addition to systemic steroid therapy on hearing improvement for the treatment of idiopathic sudden hearing loss.
SUBJECTS AND METHOD
Retrospective medical chart reviews of 500 patients who had been diagnosed with unilateral idiopathic sudden hearing loss between May 2006 and April 2014 were performed. Then, we conducted a multiple linear regression analysis using the data of individual patients.
RESULTS
Better hearing gain was associated with low tone hearing loss (p<0.001), better initial contralateral hearing (p<0.001), and the absence of dizziness (p=0.015). Patients who underwent intratympanic steroid treatment as salvage treatment showed a lower hearing gain (p<0.001). Zinc supplementation was effective for the treatment of patients with mild hearing loss (p<0.001). On the contrary, significant improvements in hearing gain were found in patients with profound hearing loss who were treated with an additional lipoprostaglandin E1 (p<0.001).
CONCLUSION
An additional use of zinc and lipoprostaglandin E1 may enhance hearing improvement for the treatment of idiopathic sudden hearing loss.

Keyword

Profound; Prostaglandin; Steroid; Sudden hearing loss

MeSH Terms

Dizziness
Hearing
Hearing Loss
Hearing Loss, Sudden*
Humans
Linear Models
Retrospective Studies
Zinc*
Zinc