Korean J Otorhinolaryngol-Head Neck Surg.  2008 Jan;51(1):22-27.

The Study for Combined Therapeutic Effects of Lipoprostaglandin E1 with Carbogen Inhalation on Sudden Sensorineural Hearing Loss

• Kim MG

Abstract

BACKGROUND AND OBJECTIVES: Sudden sensorineural hearing loss (SSNHL) is a disease, which occur rapidly within 3 days with unknown causes. Vascular and viral mechanisms are considered as the main cause, but an etiologcal background for vascular factors is more assumed. Carbogen inhalation and lipoprostaglandin E1, both of which have vasodilation effects, are used as treatment modalities in SSNHL. The purpose of this study was to recognize the effectiveness of lipo-PGE1 combined with carbogen inhalation, and to compare with other treatment modalities.
SUBJECTS AND METHOD
The study group consisted of 224 patients (110 males, 114 females) diagnosed with SSNHL. We retrospectively reviewed patients who were admitted and treated from January 2001 to December 2005. All patients were treated with carbogen inhalation and drugs. Stellate ganglion block (SGB) and lipo-PGE1 were applied to patients selectively. Eighty-six patients (DCP group) were treated with lipo-PGE1, 49 patient (DCS group) with SGB, and 89 patients (DC group) without SGB.
RESULTS
The overall recovery rates after the treatment were 59.8%. Therapeutic results of lipo-PGE1 group were better than those of other groups.
CONCLUSION
Although various treatments for SSNHL have been proposed, lipo-PGE1 and carbogen inhalation were more effective and lipo-PGE1 is considered to be more helpful for SSNHL.

Keyword

Carbogen inhalation; Lipo-PGE1; Sudden hearing loss

MeSH Terms

Alprostadil
Carbon Dioxide
Hearing Loss, Sensorineural
Hearing Loss, Sudden
Humans
Inhalation
Male
Oxygen
Retrospective Studies
Stellate Ganglion
Vasodilation
Alprostadil
Carbon Dioxide
Oxygen