Korean J Otorhinolaryngol-Head Neck Surg.  2014 Oct;57(10):703-706. 10.3342/kjorl-hns.2014.57.10.703.

Change of Voice Quality before and after Treatment of Short-Term Therapy with Proton Pump Inhibitor in Laryngopharyngeal Reflux

• Lee JH
• Shin HA
• Choi HS
• Kim CY
• Jeong SW
• Chang JH

• KMID: 2277824
• DOI: http://doi.org/10.3342/kjorl-hns.2014.57.10.703

Abstract

BACKGROUND AND OBJECTIVES
The aim of this study was to verify that voice analysis could be an alternate tool for the evaluation of proton pump inhibitor treatment of laryngopharyngeal reflux (LPR).
SUBJECTS AND METHOD
Twenty-two patients with LPR symptoms underwent laryngoscopy, stroboscopy and their reflux finding index (RFI) were evaluated. Subjective reflux symptom scores (RSS) and voice handicap index (VHI) were completed at the baseline. All patients underwent voice analysis. Thereafter, patients had short-term proton pump inhibitor therapy for 6 weeks. The RFI, RSS, VHI and voice analysis were repeated during the last week of the treatment.
RESULTS
RFI was improved and both RSS and VHI were improved after the treatment. RSS and VHI were significantly correlated. In voice analysis, shimmer significantly improved and harmony to noise ratio (HNR) also improved.
CONCLUSION
Voice analysis can be indicators of treatment results of laryngopharyngeal reflux disease.

Keyword

Hoarseness; Laryngopharyngeal reflux; Proton pump inhibitor; Voice parameters

MeSH Terms

Hoarseness
Humans
Laryngopharyngeal Reflux*
Laryngoscopy
Noise
Proton Pumps*
Stroboscopy
Voice
Voice Quality*
Proton Pumps