Korean J Pathol.  2010 Feb;44(1):97-100.

A Case of Endocrine Mucin-Producing Sweat Gland Carcinoma Co-existing with Mucinous Carcinoma: A Case Report

• Chang S
• Shim SH
• Joo M
• Kim H
• Kim YK

Abstract

An endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a rare skin tumor that most commonly occurs on the eyelids of elderly women. This tumor is morphologically analogous to endocrine ductal carcinoma in situ and solid papillary carcinoma of the breast. We describe one case of a 51-year-old male with an EMPSGC co-existing with mucinous carcinoma of the eyelid. The tumor was composed of dilated ducts with a smooth border and was partially filled with a papillary proliferation. Tumor cells were uniform, small-to-medium in size, and oval-to-polygonal with light eosinophilic cytoplasm. Nuclei were bland with diffusely stippled chromatin and inconspicuous nucleoli. Tumor cells expressed chromogranin, synaptophysin, estrogen and progesterone receptors, cytokeratin 7, and epithelial membrane antigen.

Keyword

Sweat gland neoplasms; Adenocarcinoma, mucinous; Carcinoma, neuroendocrine

MeSH Terms

Adenocarcinoma, Mucinous
Aged
Breast
Carcinoma, Intraductal, Noninfiltrating
Carcinoma, Neuroendocrine
Carcinoma, Papillary
Chromatin
Cytoplasm
Eosinophils
Estrogens
Eyelids
Female
Humans
Keratin-7
Light
Male
Middle Aged
Mucin-1
Mucins
Receptors, Progesterone
Skin
Sweat
Sweat Gland Neoplasms
Sweat Glands
Synaptophysin
Chromatin
Estrogens
Keratin-7
Mucin-1
Mucins
Receptors, Progesterone
Synaptophysin